forced expression of pgc-1a Search Results


gene exp ppargc1a hs00173304 m1  (Thermo Fisher)
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plasmid pcmv6 myc pgc 1α  (OriGene)
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membrane  (Proteintech)
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anti pgc 1a  (Santa Cruz Biotechnology)
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rabbit anti pgc1a  (Novus Biologicals)
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pgc 1a  (Santa Cruz Biotechnology)
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antibodies against pgc1 α  (ABclonal Biotechnology)
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The SnRNA-seq analysis of the hippocampus in aged mice after anesthesia and surgery. (A) UMAP dimensionality reduction maps of ten cell types in hippocampus; (B) Dot plot showed specific highly expressed genes in each cell type of hippocampus; (C) Secondary clustering identified four microglial subpopulations with distinct transcriptomic profiles; (D) Heatmap showed the top ten DEGs of each subpopulation; (E) Dot plot showed the expression of the marker genes in different subpopulations; (F) Pie charts showed the proportion of microglial subpopulations relative to the total microglia; (G) Bar graphs showed the relative change in the Sur group compared with the Con group, calculated as (proportion in the Sur group- proportion in the Con group)/proportion in the Con group; (H) The volcanic plot illustrated the expression of microglial <t>Ppargc1a</t> in the Sur group compare to the Con group; (I) KEGG enrichment analysis of hippocampal microglia; (J) GO enrichment analysis of hippocampal microglia; (K) Comparisons for the changes of cell-cell interactions in all pairs of cells between the Sur and Con groups. Red edges represented increased signalings in the Sur group, blue edges represented increased signalings in the Con group; (L) Comparisons for the changes of cell-cell interactions in all pairs of microglia, inhibitory neuron and excitatory neuron between the Sur and Con groups.
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pcdna4 myc pgc 1a  (Addgene inc)
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The SnRNA-seq analysis of the hippocampus in aged mice after anesthesia and surgery. (A) UMAP dimensionality reduction maps of ten cell types in hippocampus; (B) Dot plot showed specific highly expressed genes in each cell type of hippocampus; (C) Secondary clustering identified four microglial subpopulations with distinct transcriptomic profiles; (D) Heatmap showed the top ten DEGs of each subpopulation; (E) Dot plot showed the expression of the marker genes in different subpopulations; (F) Pie charts showed the proportion of microglial subpopulations relative to the total microglia; (G) Bar graphs showed the relative change in the Sur group compared with the Con group, calculated as (proportion in the Sur group- proportion in the Con group)/proportion in the Con group; (H) The volcanic plot illustrated the expression of microglial <t>Ppargc1a</t> in the Sur group compare to the Con group; (I) KEGG enrichment analysis of hippocampal microglia; (J) GO enrichment analysis of hippocampal microglia; (K) Comparisons for the changes of cell-cell interactions in all pairs of cells between the Sur and Con groups. Red edges represented increased signalings in the Sur group, blue edges represented increased signalings in the Con group; (L) Comparisons for the changes of cell-cell interactions in all pairs of microglia, inhibitory neuron and excitatory neuron between the Sur and Con groups.
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peroxisome proliferatoractivated receptor g coactivator pgc 1a  (R&D Systems)
94
R&D Systems peroxisome proliferatoractivated receptor g coactivator pgc 1a
The SnRNA-seq analysis of the hippocampus in aged mice after anesthesia and surgery. (A) UMAP dimensionality reduction maps of ten cell types in hippocampus; (B) Dot plot showed specific highly expressed genes in each cell type of hippocampus; (C) Secondary clustering identified four microglial subpopulations with distinct transcriptomic profiles; (D) Heatmap showed the top ten DEGs of each subpopulation; (E) Dot plot showed the expression of the marker genes in different subpopulations; (F) Pie charts showed the proportion of microglial subpopulations relative to the total microglia; (G) Bar graphs showed the relative change in the Sur group compared with the Con group, calculated as (proportion in the Sur group- proportion in the Con group)/proportion in the Con group; (H) The volcanic plot illustrated the expression of microglial <t>Ppargc1a</t> in the Sur group compare to the Con group; (I) KEGG enrichment analysis of hippocampal microglia; (J) GO enrichment analysis of hippocampal microglia; (K) Comparisons for the changes of cell-cell interactions in all pairs of cells between the Sur and Con groups. Red edges represented increased signalings in the Sur group, blue edges represented increased signalings in the Con group; (L) Comparisons for the changes of cell-cell interactions in all pairs of microglia, inhibitory neuron and excitatory neuron between the Sur and Con groups.
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gene exp ppargc1a mm00447183 m1  (Thermo Fisher)
97
Thermo Fisher gene exp ppargc1a mm00447183 m1
The SnRNA-seq analysis of the hippocampus in aged mice after anesthesia and surgery. (A) UMAP dimensionality reduction maps of ten cell types in hippocampus; (B) Dot plot showed specific highly expressed genes in each cell type of hippocampus; (C) Secondary clustering identified four microglial subpopulations with distinct transcriptomic profiles; (D) Heatmap showed the top ten DEGs of each subpopulation; (E) Dot plot showed the expression of the marker genes in different subpopulations; (F) Pie charts showed the proportion of microglial subpopulations relative to the total microglia; (G) Bar graphs showed the relative change in the Sur group compared with the Con group, calculated as (proportion in the Sur group- proportion in the Con group)/proportion in the Con group; (H) The volcanic plot illustrated the expression of microglial <t>Ppargc1a</t> in the Sur group compare to the Con group; (I) KEGG enrichment analysis of hippocampal microglia; (J) GO enrichment analysis of hippocampal microglia; (K) Comparisons for the changes of cell-cell interactions in all pairs of cells between the Sur and Con groups. Red edges represented increased signalings in the Sur group, blue edges represented increased signalings in the Con group; (L) Comparisons for the changes of cell-cell interactions in all pairs of microglia, inhibitory neuron and excitatory neuron between the Sur and Con groups.
Gene Exp Ppargc1a Mm00447183 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 97 stars, based on 1 article reviews
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Image Search Results


The SnRNA-seq analysis of the hippocampus in aged mice after anesthesia and surgery. (A) UMAP dimensionality reduction maps of ten cell types in hippocampus; (B) Dot plot showed specific highly expressed genes in each cell type of hippocampus; (C) Secondary clustering identified four microglial subpopulations with distinct transcriptomic profiles; (D) Heatmap showed the top ten DEGs of each subpopulation; (E) Dot plot showed the expression of the marker genes in different subpopulations; (F) Pie charts showed the proportion of microglial subpopulations relative to the total microglia; (G) Bar graphs showed the relative change in the Sur group compared with the Con group, calculated as (proportion in the Sur group- proportion in the Con group)/proportion in the Con group; (H) The volcanic plot illustrated the expression of microglial Ppargc1a in the Sur group compare to the Con group; (I) KEGG enrichment analysis of hippocampal microglia; (J) GO enrichment analysis of hippocampal microglia; (K) Comparisons for the changes of cell-cell interactions in all pairs of cells between the Sur and Con groups. Red edges represented increased signalings in the Sur group, blue edges represented increased signalings in the Con group; (L) Comparisons for the changes of cell-cell interactions in all pairs of microglia, inhibitory neuron and excitatory neuron between the Sur and Con groups.

Journal: International Journal of Biological Sciences

Article Title: Microglial PGC-1α alleviates synaptic damage and cognitive impairments following anesthesia and surgery by suppressing excessive synaptic pruning in aged mice

doi: 10.7150/ijbs.121472

Figure Lengend Snippet: The SnRNA-seq analysis of the hippocampus in aged mice after anesthesia and surgery. (A) UMAP dimensionality reduction maps of ten cell types in hippocampus; (B) Dot plot showed specific highly expressed genes in each cell type of hippocampus; (C) Secondary clustering identified four microglial subpopulations with distinct transcriptomic profiles; (D) Heatmap showed the top ten DEGs of each subpopulation; (E) Dot plot showed the expression of the marker genes in different subpopulations; (F) Pie charts showed the proportion of microglial subpopulations relative to the total microglia; (G) Bar graphs showed the relative change in the Sur group compared with the Con group, calculated as (proportion in the Sur group- proportion in the Con group)/proportion in the Con group; (H) The volcanic plot illustrated the expression of microglial Ppargc1a in the Sur group compare to the Con group; (I) KEGG enrichment analysis of hippocampal microglia; (J) GO enrichment analysis of hippocampal microglia; (K) Comparisons for the changes of cell-cell interactions in all pairs of cells between the Sur and Con groups. Red edges represented increased signalings in the Sur group, blue edges represented increased signalings in the Con group; (L) Comparisons for the changes of cell-cell interactions in all pairs of microglia, inhibitory neuron and excitatory neuron between the Sur and Con groups.

Article Snippet: Membranes were washed three times with TBST and blocked with 2% BSA for 2 h at room temperature, followed by overnight incubation at 4 °C with primary antibodies against PGC1-α (A12348, ABclonal), NRF-1 (A3251, ABclonal), TFAM (A3173, ABclonal), COX IV (11242-1-AP, Proteintech), ATP5A1 (14676-1-AP, Proteintech), PSD-95 (20665-1-AP, Proteintech), Synaptophysin (17785-1-AP, Proteintech), NMDAR1 (ET1703-75, HuaBio), NMDAR2A (ET1704-80, HuaBio), NMDAR2B (HA722284, HuaBio), and β-actin (R1207-1, HuaBio).

Techniques: Expressing, Marker